Heterogeneous diseases, interacting comorbidities

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• Stratification of latent subgroups in complex trials

• Mapping of association/hazard rate heterogeneity

• Handle informative censoring by competing risks

• Decontaminated survival curves

High dimensional covariates, small sample sizes

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• Risk signatures and clinical outcome prediction

• Treatment response signatures

• Replica-based overfitting decontamination

• Simulation of clinical trials